Dichloromethylenebis(phosphonic acid)
CLODRONIC ACID
CAS: 10596-23-3
Molecular Formula: CH4Cl2O6P2
Dichloromethylenebis(phosphonic acid) - Names and Identifiers
Dichloromethylenebis(phosphonic acid) - Physico-chemical Properties
| Molecular Formula | CH4Cl2O6P2 |
| Molar Mass | 244.892 |
| Density | 2.306±0.06 g/cm3(Predicted) |
| Melting Point | 249-251° |
| Boling Point | 474.7±55.0 °C(Predicted) |
| pKa | 0.75±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | Chlordronic acid is an organic compound, suitable for bone metastasis cancer, multiple myeloma, (Paget's disease) and osteoporosis caused by various reasons; treatment of hypercalcemia caused by malignant tumors; treatment Osteoporosis. |
Dichloromethylenebis(phosphonic acid) - Purification method
A method for refining and purifying disodium clodronate, the method comprising the following steps:
S1:EDTA treatment of activated carbon
Add the activated carbon to the EDTA solution, stir to make the EDTA fully contact with the activated carbon, and then wash the activated carbon until there is no chloride detection;
S2: activated carbon
Dry the activated carbon in S1 and activate it;
S3: activated carbon impurity removal
Use the activated carbon in S2 to treat the crude product solution of disodium chlorophosphate, filter, wash and control the pH of the filtrate not to exceed 3.65;
S4: crystallization and drying
Ethanol is added to the filtrate of S3 while stirring. After white crystals are precipitated, the refined product of disodium chlorophosphate is obtained by standing, filtering and drying.
Last Update：2024-04-10 22:29:15
Dichloromethylenebis(phosphonic acid) - Production method
Triisopropyl phosphonite and dibromomethane are heated and refluxed under stirring to evaporate the unreactants to obtain oily tetraisopropyl methane diphosphonate. Add it to the sodium hypochlorite solution, react, and then use chloroform to extract three times, merge the chloroform solution, evaporate most of the chloroform under reduced pressure, and cool out a white solid, which is dichloromethane diphosphonic acid tetraisopropyl ester. Add it to 1,1,2,2, 2-tetrachloroethane, heat and reflux, and evaporate 1,1,2,2, 2-tetrachloroethane under reduced pressure to obtain
The oil is recrystallized with isopropyl ether/chloroform to obtain chlorophosphonic acid.
Last Update：2024-04-10 22:29:15
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View History
Dichloromethylenebis(phosphonic acid)
2.4-D ETHYL ESTER SOLUTION 100UG/ML IN ACETONITRILE 1ML
2.2'.3.3'.4.4'.5.5'-Octachlorobiphenyl Solution
CHLOROPLATINIC ACID HEXAHYDRATEACS REAGE NT
Platinum Diammine Dinitrite Aqueous Suspension [P-Salt] as aqueous slurry This system produces bright and adherent deposits of low stress. Platinum P salt is available in the form of aqueous slurry, which is dissolved in a solution of diammonium and disodium hydrogen phosphates to provide the plating bath.
2-HYDRAZINONAPHTHALENE HYDROCHLORIDE
2-甲基-2-丙基(4-羟基-1-甲基环己基)氨基甲酸酯
Cyclopentanecarbonyl chloride, 2-methoxy-, (1S-trans)- (9CI)
3-[(4-硝基苯氧基)甲基]苯甲酸
丙烯酸金刚烷-1-基酯 (含稳定剂BHT)
2.4-D ETHYL ESTER SOLUTION 100UG/ML IN ACETONITRILE 1ML
2.2'.3.3'.4.4'.5.5'-Octachlorobiphenyl Solution
CHLOROPLATINIC ACID HEXAHYDRATEACS REAGE NT
Platinum Diammine Dinitrite Aqueous Suspension [P-Salt] as aqueous slurry This system produces bright and adherent deposits of low stress. Platinum P salt is available in the form of aqueous slurry, which is dissolved in a solution of diammonium and disodium hydrogen phosphates to provide the plating bath.
2-HYDRAZINONAPHTHALENE HYDROCHLORIDE
2-甲基-2-丙基(4-羟基-1-甲基环己基)氨基甲酸酯
Cyclopentanecarbonyl chloride, 2-methoxy-, (1S-trans)- (9CI)
3-[(4-硝基苯氧基)甲基]苯甲酸
丙烯酸金刚烷-1-基酯 (含稳定剂BHT)